For Healthcare Providers

Proven Results With BELVIQ® 10 mg Twice Daily

Clinically Proven to Work 

BELVIQ, 10 mg twice daily, can help you lose weight and improve certain health risk factors. In FDA clinical trials, people who added BELVIQ to diet and exercise were able to lose weight and improve health risk factors, such as high blood pressure, high blood sugar, and high cholesterol levels. BELVIQ was tested in two major clinical studies, one lasting a year (4,008 people) and one lasting 2 years (3,182 people).*

The combined results of these two studies showed that:

  • Almost half of people (47.1%) taking BELVIQ lost 5% or more of their body weight after 1 year of treatment, compared with those using diet and exercise alone (22.6%)

  • Some (22.4%) lost 10% or more of their body weight after 1 year of treatment, compared with those using diet and exercise alone (8.7%)

Though BELVIQ is not a treatment for cholesterol or blood pressure, people taking BELVIQ with diet and exercise had significant improvements in their blood pressure and cholesterol levels, compared with those using diet and exercise alone. It is not known if BELVIQ changes your risk of heart problems, stroke, or death due to heart problems or stroke.

BELVIQ® can help you manage your weight loss — In a major clinical trial, people taking BELVIQ
10 mg twice daily were able to lose weight and maintain weight loss up to 2 years. In the 2-year study, almost half of people who completed the first year continued on in Year 2. Patients in all groups who completed the study regained weight but remained below their starting weight.

BELVIQ® helps people living with extra weight with type 2 diabetes lose weight — BELVIQ 10 mg twice daily was also tested in a study involving 604* men and women living with type 2 diabetes and extra weight. Results showed that more than a third of people taking BELVIQ with diet and exercise (37.5%) lost 5% or more of their body weight, compared with those using diet and exercise alone (16.1%). And, 16.3% of patients taking BELVIQ with diet and exercise lost 10% or more of thier body weight, compared with those using diet and exercise alone (4.4%). Though BELVIQ is not a treatment for type 2 diabetes, the BELVIQ group showed significant improvements in blood sugar levels, compared with those using diet and exercise alone.

Patients who took BELVIQ were 3 to 4 times† more likely to achieve  ≥10% weight loss versus diet and exercise alone, in the three studies above

Patients who took BELVIQ were 3 times† more likely to achieve  ≥5% weight loss versus diet and exercise alone, in the three studies above.

†This data was determined based upon odds ratio. Odds ratio is the likelihood of achieving the weight loss goal with medication versus without.

The most common side affects for BELVIQ were headache, dizziness, fatigue, nausea, dry mouth, constipation, low blood sugar (in patients with type 2 diabetes), and back pain.

Discontinuation rates due to side effects were similar between BELVIQ® and Placebo, 8.6% and 6.7% respectively. The most common side effects leading to discontinuation more often with BELVIQ than placebo were headache, depression, and dizziness.

*Nearly half of all participants completed the studies in overweight patients without diabetes; nearly two-thirds of the participants completed the study in overweight patients with diabetes.

Also available BELVIQ XR® 

Once-Daily BELVIQ XR® provides support throughout the day. Each 20 mg orange-colored tablet releases medicine in your body throughout the day. The approval of Once-Daily BELVIQ XR® 20 mg extended-release tablet is based on the results of a clinical study that found this formulation to be bioequivalent (i.e., performs in the same manner) to the twice-daily BELVIQ® 10 mg immediate-release tablet.

The bioequivalence and bioavailability of Once-Daily BELVIQ XR 20 mg compared with twice-daily BELVIQ 10 mg was based on a Phase 1 registrational clinical trial among healthy adult subjects. Bioequivalence was demonstrated between BELVIQ XR and BELVIQ.

Important Safety Information

Valvular heart disease: Some people taking medicines like BELVIQ or BELVIQ XR have had heart valve problems. Call your Healthcare Provider right away if you experience trouble breathing; swelling of the arms, legs, ankles, or feet; dizziness, fatigue, or weakness that will not go away; or fast or irregular heartbeat. Before taking BELVIQ or BELVIQ XR, tell your Healthcare Provider if you have or have had heart problems.

Please see additional Important Safety Information below for BELVIQ® and BELVIQ XR®.

Our Discussion Guide Can Help You Talk to Your Healthcare Provider About Weight-Loss Treatment Options.
Save on BELVIQ®
and BELVIQ XR®
Get ongoing savings.*
*Restrictions Apply
BELIEVE EVERYDAY
SUPPORT®
It’s your time. Take advantage of our exclusive support program, featuring expert advice, recipes, and tools from our partner at EatingWell®. And be sure to check out the physical activity and food intake app to help you track your progress!

What is BELVIQ®/BELVIQ XR®?

BELVIQ/BELVIQ XR is a FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some adults (body mass index [BMI]  ≥27 kg/m2) living with extra weight, with a weight-related medical problem, or adults living with obesity (BMI  ≥30 kg/m2), lose weight and keep it off. It is not known if BELVIQ/BELVIQ XR when taken with other prescription, over-the-counter, or herbal weight-loss products is safe and effective. It is not known if BELVIQ/BELVIQ XR changes your risk of heart problems, stroke, or death due to heart problems or stroke.

Important Safety Information

  • Pregnancy: Do not take if you are pregnant or planning to become pregnant, as weight loss offers no benefit during pregnancy and BELVIQ/BELVIQ XR may harm your unborn baby.
  • Hypersensitivity reactions: Do not take if you are allergic to lorcaserin or any of the ingredients in BELVIQ/BELVIQ XR.
  • Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like reactions: Before using, tell your Healthcare Provider about all the medicines you take, especially medicines that treat depression, migraines, mental problems, or the common cold. These medicines may cause serious or life-threatening side effects if taken with BELVIQ/BELVIQ XR. Call your Healthcare Provider right away if you experience agitation, hallucinations, confusion, or other changes in mental status; coordination problems; uncontrolled muscle spasms; muscle twitching; restlessness; racing or fast heartbeat; high or low blood pressure; sweating; fever; nausea; vomiting; diarrhea; or stiff muscles.
  • Valvular heart disease: Some people taking medicines like BELVIQ/BELVIQ XR have had heart valve problems. Call your Healthcare Provider right away if you experience trouble breathing; swelling of the arms, legs, ankles, or feet; dizziness, fatigue, or weakness that will not go away; or fast or irregular heartbeat. Before taking BELVIQ/BELVIQ XR, tell your Healthcare Provider if you have or have had heart problems.
  • Changes in attention or memory: BELVIQ/BELVIQ XR may slow your thinking. You should not drive a car or operate heavy equipment until you know how BELVIQ/BELVIQ XR affects you.
  • Mental problems: Taking too much BELVIQ/BELVIQ XR may cause hallucinations, a feeling of being high or in a very good mood, or feelings of standing outside your body.
  • Depression or thoughts of suicide: Call your Healthcare Provider right away if you notice any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings, or if you have depression or thoughts of suicide.
  • Low blood sugar: Weight loss can cause low blood sugar in people taking medicines for type 2 diabetes, such as insulin or sulfonylureas. Blood sugar levels should be checked before and while taking BELVIQ/BELVIQ XR. Changes to diabetes medication may be needed if low blood sugar develops.
  • Painful erections: If you have an erection lasting more than 4 hours while on, stop taking BELVIQ/BELVIQ XR and call your Healthcare Provider or go to the nearest emergency room right away.
  • Slow heartbeat: BELVIQ/BELVIQ XR may cause your heart to beat slower.
  • Decreases in blood cell count: BELVIQ/BELVIQ XR may cause your red and white blood cell counts to decrease.
  • Increase in prolactin: BELVIQ/BELVIQ XR may increase the amount of a hormone called prolactin. Tell your Healthcare Provider if your breasts begin to make milk or a milky fluid, or if you are a male and your breasts increase in size.
  • Most common side effects of BELVIQ®/BELVIQ XR®: Headache, dizziness, fatigue, nausea, dry mouth, constipation, cough, low blood sugar (hypoglycemia) in patients with diabetes, and back pain.
  • Nursing: BELVIQ/BELVIQ XR should not be taken while breastfeeding.
  • Drug interactions: Before taking BELVIQ/BELVIQ XR, tell your Healthcare Provider if you take medicines for depression, migraines, or other medical conditions, such as: triptans; medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, selective serotonin reuptake inhibitors, selective serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors, or antipsychotics; cabergoline; linezolid (an antibiotic); tramadol; dextromethorphan (an over-the-counter (OTC) common cold/cough medicine); OTC supplements such as tryptophan or St. John’s Wort; or erectile dysfunction medicines.

BELVIQ®/BELVIQ XR® is a federally controlled substance (CIV) because it may be abused or lead to drug dependence.
For more information about BELVIQ®/BELVIQ XR® talk to your Healthcare Provider and see the full Product Information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or
call 1-800-FDA-1088.